Automated Microfluidic Cell Culture

Automated microfluidic cell culture has various advantages over manual, macroscopic cell culture, including increased precision, ease of conducting perfusion culture, direct coupling to downstream analysis systems and the potential for real-time on-chip analyses. In collaboration with Prof. Thomas Hankemeier, Leiden University, we are working toward the establishment of automated microfluidic cell culture of stem-cell derived cultures, coupled with the analytical chemical measurement of metabolite concentrations.  This quantitative data is subsequently integrated with corresponding mechanistic models of neuronal metabolism.