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Computational Tools & Methods

For large- and multiscale modelling of biochemical reaction networks.

As the complexity of the metabolic models continuously increases, more efficient modeling approaches are required. Traditionally, the COBRA field solved many important problems, including generation of tissue-specific metabolic models and in silico formulation of minimal growth medium, using mixed-integer linear programming, which scales poorly with increasing model size and complexity. We, and others, have already developed linear approximation algorithms, which have better performance 


on a large scale. We will continue to develop those algorithms and make them freely available to the research community.

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