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Molecular Systems Physiology group

Prof. Ines Thiele's Molecular Systems Physiology group studies how diet affects human health using constraint-based modeling, a computational approach assembling detailed biochemical models. These models integrate various omics data sets and predict how genetic changes and dietary alterations impact metabolism. They focus on understanding inherited and neurodegenerative diseases alongside human cell and microbe models.

Systems Biochemistry
Research Group

Prof. Ronan M.T. Fleming leads the Systems Biochemistry research group, focusing on interdisciplinary approaches involving mathematical, computational, and experimental biology. They aim to enhance the accuracy of biomolecular network models by integrating physicochemical constraints, particularly for Parkinson’s disease and inherited metabolic disorders. Their work involves optimizing experimental design and validating model predictions using data from microfluidic cell cultures of dopaminergic neurons, sourced from both healthy individuals and those with Parkinson's, generated through stem cell techniques.

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