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Parkinson's Disease

   Identification of biomarker signatures from metagenomic and metabolomic data

Increasing evidence suggests a role of human gut microbes in the development and progression of Parkinson's Disease (PD). However, how the underlying mechanisms remain to be understood. To this end, we use our comprehensive metabolic models of human gut microbes to identify potential links between the microbial and host metabolism. In particular, we are collaborating with numerous PD experts in Europe to analyse plasma metabolomic and metagenomic data from well-defined Parkinson’s 

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disease patients and healthy controls. We are using advanced statistics together with our computational, metabolic models of human gut microbes and the human host to identify candidate biomarker signature for disease diagnosis and patient stratification. Ultimately, using the host-microbiome models we aim at identifying personalised nutritional therapeutic approaches.

Further Reading:

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Baldini et al, "Parkinson's disease-associated alterations of the gut microbiome can invoke disease-relevant metabolic changes", BMC Biology, 18(60) (2020).

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Hertel et al., "Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson's Disease", Cell Reports, 29 (7), 1767-1777. (2019).

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Chen-Plotkin et al, "Finding useful biomarkers for Parkinson's disease", Science translational medicine, 2018

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